- Exie
- Enterprise
- Edna
- Eiler
- Emory
- Evansboro
- East Mill
- Erin
- Eagle Island (historical)
- East Sheffield
- Emco-Listerhill Junction
- Eoda
- Estothel
- East Point
- Enon
- Ewell
- Eleanor
- Ellis
- Elm Bluff
- Eagle Nest
- Elliott Crossroads
- East Brewton
- East Florence
- Eclectic
- Elkmont
- Emerald Mountain
- Emelle
- Epes
- Ewing Farms
- Edwardsville